Article
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
PLoS genetics - 1 Mar 2011
Chung Sharon A, Taylor Kimberly E, Graham Robert R, Nititham Joanne, Lee Annette T, Ortmann Ward A, Jacob Chaim O, Alarcón-Riquelme Marta E, Tsao Betty P, Harley John B, Gaffney Patrick M, Moser Kathy L, Petri Michelle, Demirci F Yesim, Kamboh M Ilyas, Manzi Susan, Gregersen Peter K, Langefeld Carl D, Behrens Timothy W, Criswell Lindsey A
Abstract excerpt
Systemic lupus erythematosus (SLE) is a clinically heterogeneous, systemic autoimmune disease characterized by autoantibody formation. Previously published genome-wide association studies (GWAS) have investigated SLE as a single phenotype. Therefore, we conducted a GWAS to identify genetic factors associated with anti-dsDNA autoantibody production, a SLE-related autoantibody with diagnostic and clinical...
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