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Article

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia.

The Journal of biological chemistry - 25 Dec 2020

Lemke Nora, Melis Valeria, Lauer Dilyara, Magbagbeolu Mandy, Neumann Boris, Harrington Charles R, Riedel Gernot, Wischik Claude M, Theuring Franz, Schwab Karima

Abstract excerpt

Synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Here, we examined the cellular distribution of tau protein species in human tau overexpressing line 66 mice, a transgenic mouse model akin to genetic variants of...

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Identifiers

PMID: 33127647
DOI: 10.1074/jbc.RA120.014890
PMCID: PMC7939472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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