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Article

Regulation of oxygen-glucose deprivation/reperfusion-induced inflammatory responses and M1-M2 phenotype switch of BV2 microglia by lobetyolin.

Metabolic brain disease - 1 Dec 2023

Wang Jie, Liu Xin, Wei Wenyi, Yang Jing, Li Qinqing, Chu Shifeng, Liu Pulin, Zhang Junlong, He Wenbin

Abstract excerpt

To elucidate the protective mechanism of lobetyolin on oxygen-glucose deprivation/reperfusion (OGD/R)-induced damage in BV2 microglial cells. The OGD/R model was established using a chemical modeling method to simulate in vivo brain ischemia in lobetyolin-pretreated BV2 cells. The optimum lobetyolin dosage, chemical concentration, and OGD/R modeling duration were screened. The changes in cell morphology were...

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PMID: 37837601
DOI: 10.1007/s11011-023-01292-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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