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Article

Friedelin alleviates cerebral ischemia/reperfusion injury by controlling microglial phenotypes through the reduction of TLR4-mediated ferroptosis.

Journal of pharmacological sciences - 1 Oct 2026

Zhang Hailin, Yuan Guoqiang, Dong Zhiqiang, Yang Pengyu, Yang Wenzhen, Li Jianxiong

Abstract excerpt

Friedelin (FD), a natural pentacyclic triterpene, exerts neuroprotective effects, but its role in cerebral ischemic stroke remains unknown. In this study, FD attenuated middle cerebral artery occlusion and reperfusion (MCAO/R)-induced neurological deficits, reduced infarct volume, and inhibited neuronal apoptosis in mice. Additionally, FD suppressed proinflammatory microglial phenotype and proinflammatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42632749
DOI: 10.1016/j.jphs.2026.07.004

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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