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Article

C16 peptide and angiopoietin-1 protect against LPS-induced BV-2 microglial cell inflammation.

Life sciences - 1 Sept 2020

Fu Xiaoxiao, Chen Haohao, Han Shu

Abstract excerpt

AIMS: Pathological alterations in the brain can cause microglial activation (MA). Thus, inhibiting MA could provide a new approach for treating neurodegenerative disorders. MAIN METHODS: To investigate the effect of C16 peptide and angiopoietin-1 (Ang1) on inflammation following MA, we stimulated microglial BV-2 cells with lipopolysaccharide (LPS) and used dexmedetomidine (DEX) as a positive control. Specific...

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PMID: 32502544
DOI: 10.1016/j.lfs.2020.117894

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