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Article

Roflumilast attenuates neuroinflammation post retinal ischemia/reperfusion injury by regulating microglia phenotype via the Nrf2/STING/NF-κB pathway.

International immunopharmacology - 1 Nov 2023

Guo Yuyan, Ou Chunlian, Zhang Naiyuan, Liu Qiong, Xiong Ke, Yu Jian, Cheng Hao, Chen Linjiang, Ma Ming, Xu Jing, Wu Jing

Abstract excerpt

PURPOSE: The abnormal polarisation of microglial cells (MGs) following retinal ischemia/reperfusion (RIR) initiates neuroinflammation and progressive death of retinal ganglion cells (RGCs), causing increasingly severe and irreversible visual dysfunction. Roflumilast (Roflu) is a promising candidate for treating neuroinflammatory diseases. This study aimed to explore whether Roflu displayed a cytoprotective effect...

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Identifiers

PMID: 37751655
DOI: 10.1016/j.intimp.2023.110952

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