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Article

Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease

13 Oct 2023

Abstract excerpt

Abstract Nephrolithiasis is highly prevalent and associated with the increased risk of kidney cancer. The tumor suppressor von Hippel-Lindau (VHL) is critical for renal cancer development, however, its role in kidney stone disease has not been fully elucidated until now. Here we reported VHL expression was upregulated in renal epithelial cells upon exposure to crystal. Utilizing Vhl +/mu mouse model, depletion of...

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PMID: 37833251
DOI: 10.1038/s41419-023-06185-1

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