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SUV39H1 deficiency suppresses clear cell renal cell carcinoma growth by inducing ferroptosis

30 Sept 2020

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is a common kidney malignancy characterized by a poor prognosis. Suppressor of variegation 3–9 homolog 1 (SUV39H1), which encodes a histone H3 lysine 9 methyltransferase, has been reported to act as an oncogene in many cancers. However, it is unclear whether SUV39H1 is involved in ccRCC. Here, we report that SUV39H1 expression is frequently upregulated in ccRCC tumors and...

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PMID: 33643820
DOI: 10.1016/j.apsb.2020.09.015

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