Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder

Abstract excerpt

<h4>ABSTRACT</h4> Chronic kidney disease–mineral and bone disorder (CKD-MBD) presents with extra-skeletal calcification and renal osteodystrophy (ROD). The origins of ROD likely lie with elevated uremic toxins and/or an altered hormonal profile but the cellular events responsible remain unclear. Here, we report that stalled mitophagy contributes to mitochondrial dysfunction in bones of a CKD-MBD mouse model, and...

Topics

Open a Topic to create a Post that cites this publication.

• Autophagy in Disease and Therapy
• Bone and Joint Diseases
• Bone Metabolism and Diseases
• Dialysis and Renal Disease Management
• Metabolism and Genetic Disorders
• Mitochondrial Function and Pathology
• Organ Transplantation Techniques and Outcomes
• Osteoarthritis Treatment and Mechanisms

Identifiers and source

Literature Corpus work

8133a027-4a20-5055-891b-f74f13692d59

DOI

10.1101/2023.12.26.573355