SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signaling pathway in the absence of VHL

Abstract excerpt

Renal fibrosis is the final development pathway and the most common pathological manifestation of chronic kidney disease. An important intrinsic cause of renal fibrosis is epigenetic alterations. SET domain–containing 2 (SETD2) is the sole histone H3K36 trimethyltransferase, catalyzing H3K36 dimethylation to trimethylation. There is evidence that SETD2-mediated epigenetic alterations are implicated in many disease...

Topics

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• Cancer Genomics and Diagnostics
• Disease Models, Animal
• Embryonic Development
• Epigenetics and DNA Methylation
• Histone-Lysine N-Methyltransferase
• Mice
• Mutation
• Renal cell carcinoma treatment

Identifiers and source

Literature Corpus work

8813cc86-6a56-58e8-bfa1-246c802838ec

DOI

10.1101/2022.09.10.507394