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Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by Limiting pyroptosis

8 May 2025

Abstract excerpt

BACKGROUND: Acute kidney injury (AKI) is a critical clinical syndrome with high morbidity, mortality, and no effective treatment in clinical practice. The role of the Signal Transducer and Activator of Transcription 3 (Stat3) in AKI remains controversial, and its complex regulatory mechanisms must be further explored. METHODS: We generated renal tubular epithelial cells Stat3 conditional knockout (cKO) mice and...

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PMID: 40344718
DOI: 10.1016/j.ebiom.2025.105739

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