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Article

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum.

The Journal of infectious diseases - 1 May 2017

Siddiqui Ghizal, Srivastava Anubhav, Russell Adrian S, Creek Darren J

Abstract excerpt

Background: The emergence of artemisinin resistance in the malaria parasite Plasmodium falciparum poses a major threat to the control and elimination of malaria. Certain point mutations in the propeller domain of PfKelch13 are associated with resistance, but PfKelch13 mutations do not always result in clinical resistance. The underlying mechanisms associated with artemisinin resistance are poorly understood, and...

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PMID: 28368494
DOI: 10.1093/infdis/jix156

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