Article

Genetic suppression interactions are highly conserved across genetic backgrounds

2024-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Genetic suppression occurs when the phenotypic defects caused by a deleterious mutation are rescued by another mutation. Suppression interactions are of particular interest for genetic diseases, as they identify ways to reduce disease severity, thereby potentially highlighting avenues for therapeutic intervention. To what extent suppression interactions are influenced by the genetic background i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68ba67ff-cb60-5363-9306-a2c73a7f556d
DOI: 10.1101/2024.08.28.610086

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic suppression interactions are highly conserved across genetic backgroundsDOI 10.1101/2024.08.28.610086Read

Genetic suppression interactions are highly conserved across genetically diverse yeast isolates.Semantic proximity Read

Mechanisms of suppression: The wiring of genetic resilience.Semantic proximity Read

Suppression mechanisms: themes from variations.Semantic proximity Read

Genetic suppression: Extending our knowledge from lab experiments to natural populations.Semantic proximity Read

Global analysis of suppressor mutations that rescue human genetic defectsSemantic proximity Read

Global analysis of suppressor mutations that rescue human genetic defects.Semantic proximity Read

Diverse natural variants suppress mutations in hundreds of essential genesSemantic proximity Read

The modifiers that cause changes in gene essentialitySemantic proximity Read

Natural variants suppress mutations in hundreds of essential genes.Semantic proximity Read

Fitness Trade-Offs Lead to Suppressor Tolerance in Yeast.Semantic proximity Read

Co-occurrence of essential gene dispensability and bypass suppressor mutations across speciesSemantic proximity Read

Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell.Semantic proximity Read