Article

Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma

2023-01-06

Abstract excerpt

Multiple large-scale tumor genomic profiling efforts have been undertaken in osteosarcoma, however, little is known about the spatial and temporal intratumor heterogeneity and how it may drive treatment resistance. We performed whole-genome sequencing of 37 tumor samples from eight patients with relapsed or refractory osteosarcoma. Each patient had at least one sample from a primary site and a metastatic or relaps...

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Literature Corpus work: aea72a86-c823-59e3-9139-f3cfab187a72
DOI: 10.1101/2023.01.05.522765

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