Article

Clonality and timing of relapsing colorectal cancer metastasis revealed through whole-genome single-cell sequencing

2022-03-04

Abstract excerpt

<h4>BACKGROUND</h4> Recurrence of tumor cells following local and systemic therapy is a significant hurdle in cancer. Most patients with metastatic colorectal cancer (mCRC) will relapse, despite resection of the metastatic lesions. A better understanding of the evolutionary history of recurrent lesions is thus required to identify the spatial and temporal patterns of metastatic progression and expose the genetic d...

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Literature Corpus work: 648e5a0f-4251-5200-8886-4565ebcca7d4
DOI: 10.1101/2022.03.03.22271700

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