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Integration of multi-omics analysis reveals metabolic alterations of B lymphocytes in systemic lupus erythematosus

10 May 2024

Abstract excerpt

OBJECTIVE: To link changes in the B-cell transcriptome from systemic lupus erythematosus (SLE) patients with those in their macroenvironment, including cellular and fluidic components. METHODS: Analysis was performed on 363 patients and 508 controls, encompassing transcriptomics, metabolomics, and clinical data. B-cell and whole-blood transcriptomes were analysed using DESeq and GSEA. Plasma and urine...

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PMID: 38735509
DOI: 10.1016/j.clim.2024.110243

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