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Notch signaling: An emerging therapeutic target for cancer treatment

1 Sept 2015

Abstract excerpt

The Notch pathway is involved in cell proliferation, differentiation and survival. The Notch signaling pathway is one of the most commonly activated signaling pathways in cancer. Alterations include activating mutations and amplification of the Notch pathway, which play key roles in the progression of cancer. Accumulating evidence suggests that the pharmacological inhibition of this pathway can overcome...

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PMID: 26341688
DOI: 10.1016/j.canlet.2015.07.048

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