Article

Altered transcription factor binding events predict personalized gene expression and confer insight into functional cis-regulatory variants

2017-12-03

Abstract excerpt

Deciphering the functional roles of cis -regulatory variants is a critical challenge in genome analysis and interpretation. We hypothesize that altered transcription factor (TF) binding events are a central mechanism by which cis -regulatory variants impact gene expression. We present TF2Exp, the first gene-based framework (to our knowledge) to predict the impact of altered TF binding on personalized gene expres...

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Literature Corpus work: acf29060-5ca0-5087-8a22-4d413ed32b71
DOI: 10.1101/228155

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