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Article

Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells.

American journal of human genetics - 14 May 2010

Dombroski Beth A, Nayak Renuka R, Ewens Kathryn G, Ankener Wendy, Cheung Vivian G, Spielman Richard S

Abstract excerpt

The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) results in the condition called "ER stress," which induces the unfolded protein response (UPR), a complex cellular process that includes changes in expression of many genes. Failure to restore homeostasis in the ER is associated with human diseases. To identify the underlying changes in gene expression in response to ER stress,...

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Identifiers

PMID: 20398888
DOI: 10.1016/j.ajhg.2010.03.017
PMCID: PMC2869002

Genes

INHBE
VLDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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