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Article

The dynamic effect of genetic variation on the in vivo ER stress transcriptional response in different tissues.

G3 (Bethesda, Md.) - 30 May 2022

Russell Nikki D, Chow Clement Y

Abstract excerpt

The genetic regulation of gene expression varies greatly across tissue-type and individuals and can be strongly influenced by the environment. Many variants, under healthy control conditions, may be silent or even have the opposite effect under diseased stress conditions. This study uses an in vivo mouse model to investigate how the effect of genetic variation changes with cellular stress across different...

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Identifiers

PMID: 35485945
DOI: 10.1093/g3journal/jkac104
PMCID: PMC9157157

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