Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers' Brain Health: A Systematic Review.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Feb 2024

Aravena José M, Lee Jakyung, Schwartz Anna E, Nyhan Kate, Wang Shi-Yi, Levy Becca R

Abstract excerpt

BACKGROUND: Apolipoprotein-E (APOE) ε4 and ε2 are the most prevalent risk-increasing and risk-reducing genetic predictors of Alzheimer's disease, respectively. However, the extent to which societal factors can reduce the harmful impact of APOE-ε4 and enhance the beneficial impact of APOE-ε2 on brain health has not yet been examined systematically. METHODS: To fill this gap, we conducted a systematic review...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E2

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Biomarkers

Share to Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 37792627
DOI: 10.1093/gerona/glad237
PMCID: PMC10803122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers' Brain Health: A Systematic Review.PMID 37792627Read ↗

Leading determinants of incident dementia among individuals with and without the apolipoprotein E ε4 genotype: a retrospective cohort study.Semantic proximity Read ↗

Social Environment, Lifestyle, and Genetic Predisposition With Dementia Risk: A Long-Term Longitudinal Study Among Older Adults.Semantic proximity Read ↗

Unequal expression: Social position modulates APOE genotype risk of dementia.Semantic proximity Read ↗

Social Determinants of Health, Genetic Susceptibility, and Risk of Dementia: A Prospective Cohort Study.Semantic proximity Read ↗

Association of Early Life Risk Factors and APOE ε4 With Incident Dementia: Evidence From 14 Years of U.S. Data.Semantic proximity Read ↗

Association of Early Life Risk Factors and APOE ε4 with Incident Dementia: Evidence from 14 Years of Data from the U.S. Health and Retirement StudySemantic proximity Read ↗

APOE genotype and cognitive change in young, middle-aged, and older adults living in the community.Semantic proximity Read ↗

Education and Cardiovascular Health as Effect Modifiers of APOE ε4 on Dementia: The Atherosclerosis Risk in Communities Study.Semantic proximity Read ↗

Sex-Specific Protective Effects of APOE ε2 on Cognitive Performance.Semantic proximity Read ↗

Social support may buffer the effect of APOE ε4 allele on cognition in older adults.Semantic proximity Read ↗

Education halves the risk of dementia due to apolipoprotein ε4 allele: a collaborative study from the Swedish brain power initiative.Semantic proximity Read ↗

Differential moderation effects of ApoE and 5-HTTLPR genotypes on social vulnerability in predicting mortality among community-dwelling middle-aged and older adults: a nationwide population-based study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.