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Article

Unequal expression: Social position modulates APOE genotype risk of dementia.

PloS one - 1 Jan 2025

Aravena José M, Chen Xi, Levy Becca R

Abstract excerpt

BACKGROUND: Although social position plays a pivotal role in cognitive aging, most dementia prevention strategies and risk prediction models continue to emphasize biomedical and genetic factors (particularly APOE status). This disconnect raises critical questions about how social environments may shape the effect of genetic risk on dementia. We examined how APOE alleles interact with social adversity to determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41264567
DOI: 10.1371/journal.pone.0335846
PMCID: PMC12633912

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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