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Article

Social support may buffer the effect of APOE ε4 allele on cognition in older adults.

Journal of Alzheimer's disease : JAD - 1 Dec 2024

Payen Ameanté, Bateman James R, Dhanavanthri Muralidhara Sneha, Sachs Bonnie C, Cleveland Maryjo, Yang Mia, Lockhart Samuel N, Craft Suzanne, Bennett Jeanette M

Abstract excerpt

Apolipoprotein E (APOE) ε4 is a genetic risk factor for Alzheimer's disease (AD). Social support may confer protection against cognitive decline even in the presence of APOE ε4. We examined the relationship among APOE ε4 allele(s) carrier status, social support (overall and sub-sources), and cognition in 115 older adults (72.24 ± 8.29 years; 71.3% female). APOE ε4 carrier status moderated social support's effect...

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Identifiers

PMID: 39584285
DOI: 10.1177/13872877241293811
PMCID: PMC12744914

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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