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Article

Triggering receptor expressed on myeloid cells-1 (TREM-1) deficiency augments BAFF production to promote lupus progression.

Journal of autoimmunity - 1 Mar 2017

Liu Chi-Jui, Tsai Chang-Youh, Chiang Ssu-Hsuan, Tang Shye-Jye, Chen Nien-Jung, Mak Tak Wah, Sun Guang-Huan, Sun Kuang-Hui

Abstract excerpt

Sensing of nucleic acids by pattern recognition receptors is the key for the initiation and development of systemic lupus erythematosus (SLE). Triggering receptor expressed on myeloid cells-1 (TREM-1) is a novel innate immune receptor, which can amplify Toll-like receptor (TLR)-induced inflammatory responses. Although patients with lupus exhibit increased serum levels of soluble TREM-1 (sTREM-1), the role of...

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B-Cell Activating Factor
Dendritic Cells
Disease Progression
Lupus Erythematosus, Systemic
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Severity of Illness Index

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Identifiers

PMID: 28089248
DOI: 10.1016/j.jaut.2016.12.010

Genes

TLR9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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