Article
Toll-like receptors control activation of adaptive immune responses.
Nature immunology - 1 Oct 2001
Schnare M, Barton G M, Holt A C, Takeda K, Akira S, Medzhitov R
Abstract excerpt
Mechanisms that control the activation of antigen-specific immune responses in vivo are poorly understood. It has been suggested that the initiation of adaptive immune responses is controlled by innate immune recognition. Mammalian Toll-like receptors play an essential role in innate immunity by recognizing conserved pathogen-associated molecular patterns and initiating the activation of NF-kappaB and other...
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