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Article

Whole-Exome Sequencing Reveals High Mutational Concordance between Primary and Matched Recurrent Triple-Negative Breast Cancers.

Genes - 25 Aug 2023

Kaur Jaspreet, Chandrashekar Darshan S, Varga Zsuzsanna, Sobottka Bettina, Janssen Emiel, Gandhi Khanjan, Kowalski Jeanne, Kiraz Umay, Varambally Sooryanarayana, Aneja Ritu

Abstract excerpt

PURPOSE: Triple-negative breast cancer (TNBC) is a molecularly complex and heterogeneous breast cancer subtype with distinct biological features and clinical behavior. Although TNBC is associated with an increased risk of metastasis and recurrence, the molecular mechanisms underlying TNBC metastasis remain unclear. We performed whole-exome sequencing (WES) analysis of primary TNBC and paired recurrent tumors to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37761830
DOI: 10.3390/genes14091690
PMCID: PMC10531222

Genes

MAP3K1
MUC16
MUC3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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