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Article

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.

The Journal of clinical investigation - 1 Jan 2016

Hedberg Matthew L, Goh Gerald, Chiosea Simion I, Bauman Julie E, Freilino Maria L, Zeng Yan, Wang Lin, Diergaarde Brenda B, Gooding William E, Lui Vivian W Y, Herbst Roy S, Lifton Richard P, Grandis Jennifer R

Abstract excerpt

BACKGROUND: Recurrence and/or metastasis occurs in more than half of patients with head and neck squamous cell carcinoma (HNSCC), and these events pose the greatest threats to long-term survival. We set out to identify genetic alterations that underlie recurrent/metastatic HNSCC. METHODS: Whole-exome sequencing (WES) was performed on genomic DNA extracted from fresh-frozen whole blood and patient-matched tumor...

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Source

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Identifiers

PMID: 26619122
DOI: 10.1172/JCI82066
PMCID: PMC4701554

Genes

DDR2
ITPR3
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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