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Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions.

BMC cancer - 1 Oct 2020

Akahane Toshiaki, Kanomata Naoki, Harada Oi, Yamashita Tetsumasa, Kurebayashi Junichi, Tanimoto Akihide, Moriya Takuya

Abstract excerpt

BACKGROUND: Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor. These additional changes may be related to tumor progression and/or drug resistance. However, breast cancer-targeted NGS is not still widely used in clinical practice to compare the genomic profiles of primary breast cancer and...

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PMID: 33004031
DOI: 10.1186/s12885-020-07432-w
PMCID: PMC7528467

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