Genomic Characterization of de novo Metastatic Breast Cancer.

doi:10.1158/1078-0432.CCR-20-1720

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Article

Genomic Characterization of de novo Metastatic Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2021

Garrido-Castro Ana C, Spurr Liam F, Hughes Melissa E, Li Yvonne Y, Cherniack Andrew D, Kumari Priti, Lloyd Maxwell R, Bychkovsky Brittany, Barroso-Sousa Romualdo, Di Lascio Simona, Jain Esha, Files Janet, Mohammed-Abreu Ayesha, Krevalin Max, MacKichan Colin, Barry William T, Guo Hao, Xia Daniel, Cerami Ethan, Rollins Barrett J, MacConaill Laura E, Lindeman Neal I, Krop Ian E, Johnson Bruce E, Wagle Nikhil, Winer Eric P, Dillon Deborah A, Lin Nancy U

Abstract excerpt

PURPOSE: In contrast to recurrence after initial diagnosis of stage I-III breast cancer [recurrent metastatic breast cancer (rMBC)], de novo metastatic breast cancer (dnMBC) represents a unique setting to elucidate metastatic drivers in the absence of treatment selection. We present the genomic landscape of dnMBC and association with overall survival (OS). EXPERIMENTAL DESIGN: Targeted DNA sequencing (OncoPanel)...

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Identifiers

PMID: 33293374
DOI: 10.1158/1078-0432.CCR-20-1720
PMCID: PMC7887078

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