Article
The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson's Disease.
Biomolecules - 25 Aug 2023
Albus Alexandra, Kronimus Yannick, Burg-Roderfeld Monika, van der Wurp Hendrik, Willbold Dieter, Ziehm Tamar, Dodel Richard, Ross Jean Alexander
Abstract excerpt
The accumulation and aggregation of alpha-synuclein (α-Syn) are pathological processes associated with Parkinson's disease, indicating that the regulation of protein is a crucial etiopathological mechanism. Interestingly, human serum and cerebrospinal fluid contain autoantibodies that recognize α-Syn. This potentially demonstrates an already existing, naturally decomposing, and protective system. Thus,...
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