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Article

Serum naturally occurring anti-TDP-43 auto-antibodies are increased in amyotrophic lateral sclerosis.

Scientific reports - 21 Jan 2021

Conti Elisa, Sala Gessica, Diamanti Susanna, Casati Marco, Lunetta Christian, Gerardi Francesca, Tarlarini Claudia, Mosca Lorena, Riva Nilo, Falzone Yuri, Filippi Massimo, Appollonio Ildebrando, Ferrarese Carlo, Tremolizzo Lucio

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) patients express significant clinical heterogeneity that often hinders a correct diagnostic definition. Intracellular deposition of TDP-43, a protein involved in RNA metabolism characterizes the pathology. Interestingly, this protein can be detected in serum, wherein cognate naturally-occurring auto-antibodies (anti-TDP-43 NAb) might be also present, albeit they have never been...

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Identifiers

PMID: 33479441
DOI: 10.1038/s41598-021-81599-5
PMCID: PMC7820419

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