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Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging

6 Apr 2015

Abstract excerpt

There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive impairment and alpha-synuclein is being explored as a biomarker in CSF, blood serum and plasma. Considering key events of aging that include proteostasis, alpha-synuclein may not only be useful...

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PMID: 25844871
DOI: 10.1371/journal.pone.0123444

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