Article
Autoantibodies against the prion protein in individuals with PRNP mutations.
Neurology - 6 Oct 2020
Frontzek Karl, Carta Manfredi, Losa Marco, Epskamp Mirka, Meisl Georg, Anane Alice, Brandel Jean-Philippe, Camenisch Ulrike, Castilla Joaquín, Haïk Stéphane, Knowles Tuomas, Lindner Ewald, Lutterotti Andreas, Minikel Eric Vallabh, Roiter Ignazio, Safar Jiri G, Sanchez-Valle Raquel, Žáková Dana, Hornemann Simone, Aguzzi Adriano
Abstract excerpt
OBJECTIVE: To determine whether naturally occurring autoantibodies against the prion protein are present in individuals with genetic prion disease mutations and controls, and if so, whether they are protective against prion disease. METHODS: In this case-control study, we collected 124 blood samples from individuals with a variety of pathogenic PRNP mutations and 78 control individuals with a positive family...
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