Article
CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies.
Genes & development - 15 May 2017
Lv Kaosheng, Jiang Jing, Donaghy Ryan, Riling Christopher R, Cheng Ying, Chandra Vemika, Rozenova Krasimira, An Wei, Mohapatra Bhopal C, Goetz Benjamin T, Pillai Vinodh, Han Xu, Todd Emily A, Jeschke Grace R, Langdon Wallace Y, Kumar Suresh, Hexner Elizabeth O, Band Hamid, Tong Wei
Abstract excerpt
Janus kinase 2 (JAK2) is a central kinase in hematopoietic stem/progenitor cells (HSPCs), and its uncontrolled activation is a prominent oncogenic driver of hematopoietic neoplasms. However, molecular mechanisms underlying the regulation of JAK2 have remained elusive. Here we report that the Casitas B-cell lymphoma (CBL) family E3 ubiquitin ligases down-regulate JAK2 stability and signaling via the adaptor...
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