PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.

doi:10.1182/blood.2022016580

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PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.

Blood - 19 Jan 2023

Chen Hongxia, Bai Yunpeng, Kobayashi Michihiro, Xiao Shiyu, Cai Wenjie, Barajas Sergio, Chen Sisi, Miao Jinmin, Meke Frederick Nguele, Vemula Sasidhar, Ropa James P, Croop James M, Boswell H Scott, Wan Jun, Jia Yuzhi, Liu Huiping, Li Loretta S, Altman Jessica K, Eklund Elizabeth A, Ji Peng, Tong Wei, Band Hamid, Huang Danny T, Platanias Leonidas C, Zhang Zhong-Yin, Liu Yan

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive blood cancer with poor prognosis. FMS-like tyrosine kinase receptor-3 (FLT3) is one of the major oncogenic receptor tyrosine kinases aberrantly activated in AML. Although protein tyrosine phosphatase PRL2 is highly expressed in some subtypes of AML compared with normal human hematopoietic stem and progenitor cells, the mechanisms by which PRL2 promotes leukemogenesis...

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PMID: 36206490
DOI: 10.1182/blood.2022016580
PMCID: PMC9936309

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