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Article

LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.

The Journal of clinical investigation - 1 Apr 2016

Cheng Ying, Chikwava Kudakwashe, Wu Chao, Zhang Haibing, Bhagat Anchit, Pei Dehua, Choi John K, Tong Wei

Abstract excerpt

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk ALL commonly associated with alterations that affect the tyrosine kinase pathway, tumor suppressors, and lymphoid transcription factors. Loss-of-function mutations in the gene-encoding adaptor protein LNK (also known as SH2B3) are found in Ph-like ALLs; however, it is not clear how LNK regulates normal B cell development or...

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Source

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Identifiers

PMID: 26974155
DOI: 10.1172/JCI81468
PMCID: PMC4811117

Genes

JAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.PMID 26974155Read ↗

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