Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy

27 Sept 2023

Abstract excerpt

The minor allele of the genetic variant rs10191329 in the DYSF-ZNF638 locus is associated with unfavorable long-term clinical outcomes in multiple sclerosis patients. We investigated if rs10191329 is associated with brain atrophy measured by magnetic resonance imaging in a discovery cohort of 748 and a replication cohort of 360 people with relapsing multiple sclerosis. We observed an association with 28% more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Sclerosis Research Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Rheumatoid Arthritis Research and Therapies

Share to RNA regulation and disease

Source

Identifiers

PMID: 37753809
DOI: 10.1002/ana.26807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain AtrophyPMID 37753809Read ↗

Brain Atrophy Associated With Risk Variant rs10191329 Extends Beyond Multiple Sclerosis.Semantic proximity Read ↗

Genetic analysis of multiple sclerosis severity identifies a novel locus and implicates CNS resilience as a major determinant of outcomeSemantic proximity Read ↗

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis.Semantic proximity Read ↗

The Multiple Sclerosis severity allele rs10191329<sup>A</sup> and cognitive function: a UK Biobank studySemantic proximity Read ↗

Relevance of Multiple Sclerosis Severity Genotype in Predicting Disease Course: A Real-World Cohort.Semantic proximity Read ↗

Not all roads lead to the immune system: the genetic basis of multiple sclerosis severitySemantic proximity Read ↗

Genome-wide association study of severity in multiple sclerosis.Semantic proximity Read ↗

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.Semantic proximity Read ↗

Increased Disability Progression in rs10191329AA Carriers with Multiple Sclerosis Is Preceded by Neurofilament Light Chain Elevations.Semantic proximity Read ↗

Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy.Semantic proximity Read ↗

A genetic basis for multiple sclerosis severity: Red herring or real?Semantic proximity Read ↗

Histone deacetylase gene variants predict brain volume changes in multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.