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Relevance of Multiple Sclerosis Severity Genotype in Predicting Disease Course: A Real-World Cohort.

Annals of neurology - 1 Mar 2024

Kreft Karim L, Uzochukwu Emeka, Loveless Sam, Willis Mark, Wynford-Thomas Ray, Harding Katharine E, Holmans Peter, Lawton Michael, Tallantyre Emma C, Robertson Neil P

Abstract excerpt

OBJECTIVE: Currently, 233 genetic loci are known to be associated with susceptibility to multiple sclerosis (MS). Two independent pivotal severity genome-wide association studies recently found the first genome-wide significant single-nucleotide variant (SNV; rs10191329A ) and several other suggestive loci associated with overall disability outcomes. It is now important to understand if these findings can...

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PMID: 37974536
DOI: 10.1002/ana.26831

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