The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis.

doi:10.1002/acn3.70157

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Article

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis.

Annals of clinical and translational neurology - 1 Nov 2025

Bsteh Gabriel, Tanavade Ruchi, Krajnc Nik, Föttinger Fabian, König Theresa, Krenn Martin, Haider Lukas, Kornek Barbara, Leutmezer Fritz, Ludwig Kerstin U, Macher Stefan, Monschein Tobias, Ponleitner Markus, Rommer Paulus, Schmied Christiane, Zebenholzer Karin, Zrzavy Tobias, Zulehner Gudrun, Di Pauli Franziska, Schmidt Axel, Hegen Harald, Pemp Berthold, Berger Thomas

Abstract excerpt

OBJECTIVE: To investigate whether the rs10191329 risk allele in the DYSF-ZNF638 locus, which is implicated in central nervous system resilience rather than immune-mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). METHODS: From a prospective observational study, we included RMS patients with ≥ 2 optical coherence tomography (OCT)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40760841
DOI: 10.1002/acn3.70157
PMCID: PMC12623831

Genes

DYSF
ZNF638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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