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Article

Histone deacetylase gene variants predict brain volume changes in multiple sclerosis.

Neurobiology of aging - 1 Jan 2013

Inkster Becky, Strijbis Eva M M, Vounou Maria, Kappos Ludwig, Radue Ernst-Wilhelm, Matthews Paul M, Uitdehaag Bernard M J, Barkhof Frederik, Polman Chris H, Montana Giovanni, Geurts Jeroen J G

Abstract excerpt

Neuroimaging measures hold promise for enhancing the detection of disease-related genetic variants. In this study, we use advanced multivariate regression methods to assess the predictive value of single nucleotide polymorphisms (SNPs) on several brain volumetric- and lesion-related neuroimaging measures in a well-characterized cohort of 326 patients with multiple sclerosis (MS). SNP selection was constrained to...

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Identifiers

PMID: 22884548
DOI: 10.1016/j.neurobiolaging.2012.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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