Increased Disability Progression in rs10191329AA Carriers with Multiple Sclerosis Is Preceded by Neurofilament Light Chain Elevations.

doi:10.1002/ana.27144

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Increased Disability Progression in rs10191329AA Carriers with Multiple Sclerosis Is Preceded by Neurofilament Light Chain Elevations.

Annals of neurology - 1 Mar 2025

Protopapa Maria, Steffen Falk, Schraad Muriel, Ruck Tobias, Öztürk Menekse, Hanuscheck Nicholas, Shin Josef, Brummer Tobias, Pape Katrin, Uphaus Timo, Meuth Sven G, Fleischer Vinzenz, Teunissen Charlotte E, De Jager Philip L, Luessi Felix, Bittner Stefan, Zipp Frauke

Abstract excerpt

OBJECTIVE: We examined the impact of the rs10191329 genetic risk variant on neuroaxonal damage as measured by serum neurofilament light chain (sNfL) levels, and disability progression in people with multiple sclerosis (pwMS). METHODS: In a cohort of pwMS (n = 740), 658 participants were prospectively monitored every 2 years for less than a decade while 82 of 740 pwMS were monitored retrospectively for up to...

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PMID: 39588882
DOI: 10.1002/ana.27144
PMCID: PMC11831884

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