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Molecular mechanism of rifampicin and isoniazid resistance in Mycobacterium tuberculosis from Bangladesh.

Tuberculosis (Edinburgh, Scotland) - 1 Nov 2012

Rahim Zeaur, Nakajima Chie, Raqib Rubhana, Zaman Khalequ, Endtz Hubert P, van der Zanden Adri G M, Suzuki Yasuhiko

Abstract excerpt

Despite having 100% coverage of directly observed treatment short-course, multi drug-resistant (MDR) tuberculosis (TB) is still increasing in Bangladesh. Early detection of MDR-TB by rapid molecular test and early initiation of treatment will effectively stop this trend. To develop rapid diagnostic tools, molecular characterization of genes conferring Mycobacterium tuberculosis resistance to rifampicin (RIF) and...

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PMID: 22863574
DOI: 10.1016/j.tube.2012.07.005

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