Evidence for the critical role of a secondary siterpoBmutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

Abstract excerpt

BACKGROUND: MDR Mycobacterium tuberculosis clinical strains that cause large outbreaks, particularly among HIV-negative patients, are likely to have undergone the most successful compensatory evolution. Hence, mutations secondary to the acquisition of drug resistance are worthy of consideration in these highly transmissible strains. Here, we assessed the role of a mutation within rpoB, rpoB V615M, secondary to...

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