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Article

Association between SLCO1B1 genetic polymorphisms and bleeding risk in patients treated with edoxaban.

Scientific reports - 25 Sept 2023

Han Ji Min, Jang Eun Jeong, Yee Jeong, Song Tae-Jin, Kim Dong-Hyeok, Park Junbeom, Gwak Hye Sun

Abstract excerpt

Since SLCO1B1 encodes the uptake transporter OATP1B1, which can influence the pharmacokinetic and pharmacodynamic profiles of edoxaban, polymorphisms in SLCO1B1 may affect the edoxaban response. This study aimed to investigate the association between SLCO1B1 gene polymorphisms and the bleeding risk in patients receiving edoxaban. We genotyped 10 single-nucleotide polymorphisms (SNPs) from the SLCO1B1 gene in...

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Identifiers

PMID: 37749323
DOI: 10.1038/s41598-023-43179-7
PMCID: PMC10520058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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