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The impact of ABCB1, CYP3A4 and CYP3A5 gene polymorphisms on apixaban trough concentration and bleeding risk in patients with atrial fibrillation.

Drug metabolism and personalized therapy - 1 Jun 2024

Skripka Alena I, Krupenin Pavel M, Kozhanova Olga N, Kudryavtseva Anna A, Fedina Ludmila V, Akmalova Kristina A, Bochkov Pavel O, Sokolova Anastasiya A, Napalkov Dmitriy A, Sychev Dmitriy A

Abstract excerpt

OBJECTIVES: Apixaban, a direct oral anticoagulant, is increasingly used worldwide for the treatment and prevention of venous thromboembolism and ischemic stroke in patients with nonvalvular atrial fibrillation (AF). Obviously, one of the ways to enhance effectiveness and safety of drug therapy is a personalized approach to therapy, which involves pharmacogenetic and pharmacokinetic tests. The study aims to...

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Identifiers

PMID: 38943286
DOI: 10.1515/dmpt-2024-0013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The impact of ABCB1, CYP3A4 and CYP3A5 gene polymorphisms on apixaban trough concentration and bleeding risk in patients with atrial fibrillation.PMID 38943286Read ↗

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