ABCB1 genotype and clinically relevant bleeding risk during extended anticoagulation therapy for pulmonary embolism: a two-phase study.

doi:10.1016/j.rpth.2026.106925

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Article

ABCB1 genotype and clinically relevant bleeding risk during extended anticoagulation therapy for pulmonary embolism: a two-phase study.

Research and practice in thrombosis and haemostasis - 1 Aug 2026

Zhang Zhu, Li Haobo, Zou Bingzhang, Ji Xiaofan, Zhang Yu, Tao Yuzhi, Xi Linfeng, Li Kuangxun, Li Huiwen, Duo Mengjie, Zhao Li, Zuo Xianbo, Zhai Zhenguo, Wang Chen

Abstract excerpt

Background: Extended direct oral anticoagulant (DOAC) therapy reduces recurrent venous thromboembolism, but clinically relevant bleeding (CRB) remains a safety concern. DOACs exhibit substantial pharmacokinetic variability among individuals, and genetic determinants of bleeding risk during extended anticoagulation remain unclear. Objectives: To explore the association between pharmacogenomic variants and CRB...

Read the complete abstract on PubMed

Topics

Humans
Pulmonary Embolism
Female
Hemorrhage
Male
ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Rivaroxaban

Aged

Middle Aged

Risk Factors

Factor Xa Inhibitors

Pharmacogenomic Variants

Genotype

Registries

Treatment Outcome

Anticoagulants

Source

Open in PubMed Open full text

Identifiers

PMID: 42774932
DOI: 10.1016/j.rpth.2026.106925
PMCID: PMC13594809

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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