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Article

Effect of Sex, Use of Pantoprazole and Polymorphisms in SLC22A1, ABCB1, CES1, CYP3A5 and CYP2D6 on the Pharmacokinetics and Safety of Dabigatran.

Advances in therapy - 1 Aug 2020

Zubiaur Pablo, Saiz-Rodríguez Miriam, Ochoa Dolores, Navares-Gómez Marcos, Mejía Gina, Román Manuel, Koller Dora, Soria-Chacartegui Paula, Almenara Susana, Abad-Santos Francisco

Abstract excerpt

INTRODUCTION: Dabigatran is a direct oral anticoagulant (DOAC) used for the treatment of several thrombotic conditions. To date, very few pharmacogenetic studies on dabigatran were published. We aimed to investigate the influence of 59 polymorphisms in 15 genes (including CES1, UGT and CYP that encode enzymes and ABCB1 and SLC that encode transporters), concomitant treatment with pantoprazole and demographic...

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Identifiers

PMID: 32564268
DOI: 10.1007/s12325-020-01414-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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