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Article

Pharmacogenetics of Bleeding and Thromboembolic Events in Direct Oral Anticoagulant Users.

Clinical pharmacology and therapeutics - 1 Sept 2021

Lähteenmäki Jaakko, Vuorinen Anna-Leena, Pajula Juha, Harno Kari, Lehto Mika, Niemi Mikko, van Gils Mark

Abstract excerpt

This study aimed to analyze associations between genetic variants and the occurrence of clinical outcomes in dabigatran, apixaban, and rivaroxaban users. This was a retrospective real-world study linking genotype data of three Finnish biobanks with national register data on drug dispensations and healthcare encounters. We investigated several single-nucleotide variants (SNVs) in the ABCG2, ABCB1, CES1, and CYP3A5...

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Identifiers

PMID: 34043814
DOI: 10.1002/cpt.2316

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