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Article

Effect of ABCB1 gene variants on rivaroxaban pharmacokinetic and hemorrhage events occurring in patients with non-valvular atrial fibrillation.

Biopharmaceutics & drug disposition - 1 Aug 2022

Zhang Dan, Qin Wei, Du Wenwen, Wang Xiaoxing, Chen Wenqian, Li Pengmei

Abstract excerpt

Hemorrhage events occur most frequently in anticoagulant therapy for non-valvular atrial fibrillation (NVAF). Rivaroxaban is used widely for routine anticoagulation care. Genetic polymorphisms are thought to contribute to the wide intraindividual variability seen in rivaroxaban metabolism and the anticoagulant response. The aim of this study was to evaluate the effect of drug transport related single-nucleotide...

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Anticoagulants
ATP Binding Cassette Transporter, Subfamily B
Atrial Fibrillation
Atrial Fibrillation Management and Outcomes
Chromatography, Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Tandem Mass Spectrometry

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PMID: 35940587
DOI: 10.1002/bdd.2327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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