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Article

Pharmacogenomic profiling of ABCB1 and CES1 in atrial fibrillation patients on dabigatran from a multiethnic Malaysian cohort.

Scientific reports - 6 Feb 2026

Tan Shirley Siang Ning, Sim Edmund Ui-Hang, Jinam Timothy Adrian, Lim Melissa Siaw Han, Chee Cassandra Sheau Mei, Anchah Lawrence, Rosli Saiful Shakirin, Sateng Beatrice Bangie Desmond, Gerunsin Jerry, Tiong Lee Len, Fong Alan Yean Yip

Abstract excerpt

Direct oral anticoagulants (DOACs) are preferred for atrial fibrillation (AF) due to their efficacy and safety, though response variabilities raises concerns about fixed-dose regimens. This study investigates the association between ABCB1 and CES1 genetic polymorphisms with Dabigatran trough drug levels (DL), clotting time (CT), and clinical outcomes in a multiethnic Malaysian cohort. A total of 180 AF patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41652091
DOI: 10.1038/s41598-026-38856-2
PMCID: PMC12932851

Genes

ABCB1
CES1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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